Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions

Rheumatoid Cachexia, a Metabolic Rheumatoid Arthritis Disorder: Pathophysiological Mechanisms, Diagnostic Tools and Current Therapeutic Strategy

Submit Manuscript | http://medcraveonline.com Abbreviations: ANO: Anorexia; BCM: Body Cell Mass; BIA: Bioelectrical Impedance Analysis; BMI: Body Mass Index; BW: Body Weight; BWC: Body Weight Loss And Composition; COX: Cyclo Oxygenase; DXA: Dual-Energy X-Ray Absorptiometry; FFM: Fat-Free Mass; FM: Fat Mass; GH: Growth Hormone; HAQ: Health Assessment Score; IGF: Insulin-Like Growth Factor; IL-1ß...

Rheumatoid Cachexia Revisited: A Metabolic Co-Morbidity in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease in which pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, play a crucial role. The chronic inflammation, combined with reduced physical activity, leads to muscle wasting whereas fat mass would be maintained; the resulting abnormal metabolic state is described as rheumatoid cachexia. Since the loss of muscle volume w...

Neurological Abnormalities in Pernicious Anemia Metabolic Mechanisms

Commentary: Rheumatoid Cachexia Revisited: A Metabolic Co-morbidity in Rheumatoid Arthritis

A commentary on Rheumatoid cachexia revisited: a metabolic co-morbidity in rheumatoid arthritis by Masuko K. The " mini review " by Masuko (1) contains a quite extensive summary of " rheumatoid cachexia " (2) [i.e., loss of muscle mass in rheumatoid arthritis (RA)], an often overlooked and misdiagnosed co-morbidity. Masuko looks at the definition of " rheumatoid cachexia, " as well as the patho...

Rheumatoid cachexia: a clinical perspective.

Rheumatoid cachexia is under-recognized in clinical practice. The loss of lean body tissue, which characterizes cachexia, is often compensated for by gain in body fat-so called 'cachectic obesity'-so that 85% or more RA patients have a normal BMI. Severe cachexia with loss of weight leads to increased morbidity and premature mortality but loss of muscle bulk with a normal BMI also associates wi...